Brock Purdy injury update: Will 49ers Quarterback start in Thursday night's game vs Rams? Here's latest update

The San Francisco 49ers reveal quarterback Brock Purdy's status for Thursday's game against the Rams after toe and shoulder injuries.

The San Francisco 49ers entered Week 5 locked in a tight NFC West race, sharing a 3-1 record with the LA Rams and Seattle Seahawks. With a Crucial divisional showdown against the Los Angeles Rams on Thursday Night Football, all eyes are on the status of 49ers quarterback Brock Purdy. According to USA Today, Purdy's status for today's game has finally been determined, ending weeks of speculation surrounding his toe and shoulder injuries, which he sustained in Week 1.

San Francisco 49ers quarterback Brock Purdy is ruled out for the crucial game against the Rams due to ongoing injuries. (AP Photo/Godofredo A. Vásquez)(AP)

Brock Purdy's game status after injury

The 49ers ruled out Purdy for today's game, delivering the disappointing news on Wednesday afternoon. The quarterback has been a regular fixture on the injury report since Week 1, when he first sustained toe and shoulder injuries.

Thursday's game will mark his third missed appearance of the 2025 season. While he played through the pain in Week 4 against the Jacksonville Jaguars, concerns grew leading up to this game, especially after coach Kyle Shanahan revealed on Monday that Purdy was still feeling sore. Purdy then failed to participate in Tuesday and Wednesday's practice before the team ruled him out of the game, as reported by USA Today.